| 2 | 9.00 | The VI Annual Disc’n for Cheetahs - Driven by Innova | B | 10-Apr-2021 |
| 4 | 6.00 | The 3rd Annual Hanna Hills Open - Sponsored by Dynamic Discs | B | 17-Apr-2021 |
| 19 | 160.00 | Dynamic Discs Open | A | 28-Apr to 30-Apr-2021 |
| 4 | 3.00 | Patriots Gold & Silver presents: The 1st Sasquatch Open | B | 15-May-2021 |
| 1 | 15.00 | The 4th Annual Dragon Ridge Open | B | 29-May-2021 |
| 1 | 8.00 | All Dam Day | C | 05-Jun-2021 |
| 2 | 18.00 | Mid America Open AMs Weekend | B | 19-Jun to 20-Jun-2021 |
| 2 | 9.00 | The Cycle Bar (Springfield East) presents: The 2nd Annual Ozarks Dam Open | B | 10-Jul-2021 |
| 3 | 4.00 | Maverick DG: Limestone Classic pres by GRIPeq | C | 17-Jul-2021 |
| 10 | 28.00 | 2021 Midwest Amateur Championships Presented by Dynamic Discs | A | 23-Jul to 25-Jul-2021 |
| 3 | 12.00 | 14th Annual Jefferson City Open Presented By Innova | B | 04-Sep to 05-Sep-2021 |
| 9 | 90.00 | 2021 PDGA Tim Selinske U.S. Masters Championships Presented by Innova | M | 09-Sep to 12-Sep-2021 |
| 2 | 24.00 | St. Louis Open | A | 17-Sep to 19-Sep-2021 |
| 1 | 9.00 | The 10th Annual Marshall Open | B | 23-Oct-2021 |
| 2 | 6.00 | The 2nd Annual Hallowed Trails Open | B | 30-Oct-2021 |
| 2 | 6.00 | The 13th Annual DGM Finale featuring “The 5th Annual Lost Woods Open” | B | 06-Nov-2021 |
| 1 | 12.00 | Elephant & Castle presents the 4th DGM Encore | B | 20-Nov-2021 |
| 2 | 8.00 | Patriot's Gold & Silver presents: 11th Annual Winter Blast | XC | 11-Dec-2021 |
